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The development of therapeutic vaccines for HIV faces several hurdles. One of the main challenges is the ability of HIV to mutate rapidly, leading to the emergence of viral strains that can escape immune recognition. Researchers are working on developing vaccines that can elicit broad and durable immune responses against multiple HIV strains. Another challenge is overcoming immune tolerance, where the immune system fails to mount a strong response against HIV due to chronic infection. Researchers are exploring strategies to break immune tolerance, such as using adjuvants to enhance vaccine immunogenicity and combining therapeutic vaccines with other immunomodulatory agents. Despite these challenges, the pursuit of therapeutic vaccines remains a high priority in HIV cure research, offering the potential to empower the immune system to control or eliminate HIV.
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