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The structure of a Kv channel is fascinating. Typically, it comprises four subunits, each containing six transmembrane segments (S1-S6). The S5 and S6 segments from each subunit form the pore through which potassium ions pass. The region between S5 and S6, known as the P-loop, dips into the membrane and forms the selectivity filter, which is highly conserved and responsible for the channel's specific permeability to K+ ions. This selectivity is achieved through a precise arrangement of amino acid residues that interact with and stabilize K+ ions while excluding other ions like sodium (Na+).
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