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How do doctors know if a breast cancer is HER2-positive? Well, it's done through tests on the tumor tissue, typically done during a biopsy. They check to see if there are too many HER2 receptors or if the HER2 gene is amplified (meaning there are extra copies of it). If the test comes back positive, it means the cancer is HER2-positive, and the patient is likely to benefit from targeted therapies designed to block HER2. These treatments work by latching onto the HER2 receptors on cancer cells, preventing them from sending growth signals. Some common HER2-targeted drugs include trastuzumab, pertuzumab, and lapatinib. These drugs are often used in combination with chemotherapy, and they have significantly improved the outcomes for patients with HER2-positive breast cancer. These treatments can reduce the risk of the cancer coming back and can also be used to treat advanced breast cancer. It's amazing how much we have learned.
